The thorough heterogeneity among patients with systemic lupus erythematosus sle causes problems regarding diagnostic accuracy in clinical. How do patients with newly diagnosed systemic lupus. Clinical and immunological criteria used in the systemic lupus international collaborating clinics slicc classi. Jun 17, 2020 classification criteria from the american college of rheumatology acr1997, the systemic lupus collaborating clinics slicc 2012, and eularacr2019 classify nonoverlapping groups of patients with sle. Classification criteria for systemic lupus erythematosus. The diagnostic accuracies of the 2012 slicc criteria and the. Validation of the systemic lupus international collaborating clinics. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. This study aims to compare the performance among the american college of rheumatology acr 1997, the systemic lupus international collaborating clinics criteria slicc and the new european league against rheumatism eularacr criteria, in a csle cohort. New lupus classification criteria presented at acrarhp. Slicc, systemic lupus international collaborating clinicsamerican college of rheumatology damage index. Objectives classification criteria are biased towards classifying longstanding disease.
We found that slicc 12 is the classification criterion for sle. Future biomarkers may be useful in distinguishing sle from other diseases and in monitoring of disease activity. In 2012, the systemic lupus international collaborating clinics slicc 12 published a new set of criteria aimed at optimizing the classification of sle. Hartman and fellow researchers in the netherlands and austria conducted a metaanalysis to compare the 2012 systemic lupus international collaborating clinics criteria slicc 12 with the revised american college of rheumatology criteria from 1997 acr97. Reprinted with permission from bertsias gk, salmon je, boumpas dt. Pdf on apr 20, 2015, iraj salehi abari published 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus find, read and cite all the research you need on researchgate.
Systemic lupus diagnostic criteria slicc calculator. Use of slicc criteria in a large, diverse lupus registry enables sle. The 1997 acr criteria have the best classification performance for juvenile sle. In 2012, the systemic lupus collaborating clinics proposed the slicc criteria for sle in view of new knowledge of autoantibodies and the importance of low complement.
Application of the 2012 systemic lupus international collaborating. Jul 14, 2014 the most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. Materials and methods patients from a latin america. In an early sle cohort the acr1997, slicc2012 and eularacr. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and. The diagnostic accuracies of the 2012 slicc criteria and. In 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc 12 to classify systemic lupus erythematosus sle. In 2012, the slicc criteria were published in an attempt to improve clinical relevance of sle criteria and address concerns with the 1997 acr criteria. In several ways, systemic lupus erythematosus sle is a rather unusual. The 2012 slicc criteria were similar to the 1997 acr criteria in terms of positive 98. Clinical criteria acute cutaneous lupus or subacute cutaneous lupus. The slicc criteria are meant to be than once was required. Jan 19, 2018 researchers referred to both the 1997 acr revised criteria and the 2012 systemic lupus international collaborating clinics slicc criteria when developing the new criteria, said martin aringer, md, steering committee cochair and chief of rheumatology at university medical center carl gustav carus in dresden, germany. Pdf 2015 acrslicc revised criteria for diagnosis of.
Performance of the 2012 systemic lupus international collaborating. Performance of the proposed slicc criteria compared with the current acr criteria in the validation sample n 690 scenarios rule 1997 acr criteria sensitivity specificity 290349 83 326341 96 0. Jan 10, 2015 in 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc 12 to classify systemic lupus erythematosus sle. The systemic lupus international collaborating clinics slicc group revised and validated the american college of rheumatology acr systemic lupus erythematosus sle classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new knowledge regarding the immunology of sle. Lupus international collaborating clinics slicc classification criteria for systemic lupus erythematosus. The demographic characteristics are detailed in table 2. Evaluation of the slicc classification criteria in patients with. Study evaluates slicc12 classification criteria for lupus. Different classification criteria for systemic lupus erythematosus sle have been proposed over many years. In 2012, the slicc criteria were published in an attempt to improve clinical relevance of sle criteria. Therapeutic opportunities in systemic lupus erythematosus.
Performance of the 2012 systemic lupus international. The systemic lupus international collaborating clinics american college of rheumatology damage index slicc acr di was developed to quantify damage that has occurred since onset of lupus. Slicc criteria for sle 2012 systemic lupus international collaborating clinics criteria for classification slicc or systemic lupus erythematosus petri m, 2012 clinical criteria acute cutaneous lupus chronic cutaneous lupus oral ulcers nonscarring alopecia synovitis in two or more joints includes tenderness and. Importantly, while the gap between the sensitivity.
New classification criteria for systemic lupus erythematosus. Notably, 2012 slicc criteria including immunological items of a positive ana above laboratory reference range, while 2019 eularacr criteria mandate the entry criterion of a positive ana titre of. At first visit, slicc criteria had higher sensitivity than acr 1997 89. Derivation and validation of the systemic lupus international. The diagnostic accuracies of the 2012 slicc criteria and the proposed eularacr criteria for systemic lupus erythematosus classification are comparable. Classification criteria sle eular acr 2018, slicc 2012. This health tool is based on the 2012 classification created by the systemic lupus international collaborating clinics slicc which is an international group that performs sle clinical research. May 15, 2019 to date there are no specific classification criteria for childhoodonset systemic lupus erythematosus csle. Criteria are cumulative and need not be present concurrently. In 2012, the systemic lupus international collaborating clinics slicc 12. The slicc criteria for sle classification requires. The systemic lupus collaborating clinics slicc revised and validated the american college of.
Slicc classification criteria for juvenile systemic lupus. Incidence and time to classification of systemic lupus. The performances of the acr 1997, slicc 2012, and eularacr. To evaluate the performance in classifying systemic lupus erythematosus by the 2012 systemic lupus international collaborating clinics criteria slicc 12, versus the revised american college of rheumatology criteria from 1997 acr97 in adult and juvenile sle patients. The median time from first disease manifestation to criteria fulfillment was shorter for the eularacr 2019 criteria 28.
Pdf the diagnostic accuracies of the 2012 slicc criteria and the. Slicc 12 criteria allow for earlier classification of sle in a multiethnic cohort of asian patients, supporting the validity of the slicc 12 criteria and its use in clinical care and research. The most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. Slicc and compare it to the acr lupus criteria, in a pediatric population. The new systemic lupus international collaborating clinics slicc 2012 classification criteria for the diagnosis of systemic lupus erythematosus was brought to improve the performance of sle diagnosis, over the american college of rheumatology acr 1997 criteria. Systemic lupus er ythema tosus sle diagnosis is positive if both are present. The diagnostic accuracies of the 2012 slicc criteria and the proposed eularacr criteria for systemic lupus erythematosus classification are comparable lupus. The performance of these criteria in colombian juvenile lupus patients is unknown. It has been shown to be a valid measure for damage and correlates with mortality. Figure 1 natural history of systemic lupus erythematosus.
Comparison among acr1997, slicc and the new eularacr. Slicc 12 criteria are more effectiveness than acr 97 score about. The present study is the first to evaluate the performance of slicc 12 in an adult european study population. For one example, thrombocytopenia was defined by the acr criteria as less than 100,000 mm3 in the absence of offending drugs 5, by the slicc criteria as lupus cases for clinical studies. Pdf the diagnostic accuracies of the 2012 slicc criteria. Investigators aimed to evaluate additional features of sle, which could be used in conjunction with existing criteria to improve diagnostic. New 2019 sle eularacr classification criteria are valuable. Slicc criteria for sle slicc classification criteria for. Compare the criteria proposed by acr 97 and slicc 12 for the diagnosis of sle and to gather information on clinical characteristics, diagnosis, and treatment. The acr american college of rheumatology 1997, slicc systemic lupus international collaborating clinics 2012, and eular european league against rheumatismacr 2019 sle classification criteria are formed based on data mainly from adult patients.
Concerns about the clinical criteria used in the current acr classification system include possible duplication of highly correlated terms relating to cutaneous lupus such as malar rash and photosensitivity and the. Thus, slicc 12 criteria were applied to confirmed sle cases in our regional sle register as well as to. Lupus international collaborating clinics slicc sle classification criteria 6 demonstrate lower sensitivity in identifying early disease, compared to established disease 7. Validation of the 2017 weighted criteria compared to the 1997. In 1998, the slicc group established a longitudinal cohort of newly diagnosed patients with lupus. Pdf 2015 acrslicc revised criteria for diagnosis of systemic. A multiple linear regression model was constructed with the 2012 slicc criteria variables as predictors and the binary outcome physician classification of sle as the outcome. These new criteria showed higher sensitivity 94% vs 86%, p criteria 4. The 2012 slicc criteria classify juvenile patients earlier than the 1997 acr. Jan 10, 2015 introduction in 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc 12 to classify systemic lupus erythematosus sle. Inclusion of noncriteria features to sle classification. Oct 22, 2015 pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. In an early sle cohort the acr1997, slicc2012 and eular. Therefore, to simplify assess clinically more relevant, allowing the inclusion of more ment, the slicc criteria require only one abnormal patients with clinically defined lupus than are included assessment of course, the result must be due to sle using the current acr criteria.
Compare the criteria proposed by acr 97 and slicc 12 for the diagnosis of sle and to gather. Although some studies in the pediatric population have slicc classification criteria for juvenile systemic lupus erythematosus. Slicc 12 criteria are more effectiveness than acr 97 score. Performance of the proposed acreular classification. Patients with biopsyconfirmed lupus nephritis could still fail to. Comparing the 1997 update of the 1982 american college of. Validation of the 2017 weighted criteria compared to the. Slicc classification criteria for juvenile systemic lupus erythematosus.
Slicc is dedicated to generating new knowledge in the field of lupus, and translating these basic and clinical research discoveries into better health care practices and policies to help provide a healthier future for people diagnosed with lupus. Slicc classification criteria for systemic lupus erythematosus 1. Evidence based medicine slicc criteria for sle cmi. Validation of the 2012 systemic lupus international. Systemic lupus erythematosus sle diagnosis is positive if both are present. Slicc criteria for systemic lupus erythematosus sle. Both the 19821997 acr classification criteria and the 2012 slicc. Ines et al reported a higher sensitivity of the 2012 slicc criteria 94% compared to the 1997 acr criteria 86%. For one example, thrombocytopenia was defined by the acr criteria as less than 100,000 mm3 in the absence of offending drugs 5, by the slicc criteria as slicc criteria for sle 2012 systemic lupus international collaborating clinics criteria for classification slicc or systemic lupus erythematosus petri m, 2012 clinical criteria acute cutaneous lupus chronic cutaneous lupus oral ulcers nonscarring alopecia. We compared the european league against rheumatism eularamerican college of rheumatology acr2019, systemic lupus international collaborating clinics slicc 2012 and acr1997 criteria in an early median 48 months systemic lupus erythematosus sle cohort. Pdf applying the 2019 eularacr lupus criteria to patients. The slicc group is an international group of investigators dedicated to clinical research on sle. Diagnostic criteria for systemic lupus erythematosus. Three sets of lupus criteria sle acr1997, sle slicc and 2019 sle eularacr criteria were tested in each group of patients.
A comparison between the classification criteria for sle slicc 2012 acr 1997 acr 1982 ara 1971 clinical criteria 1. Nov 10, 2020 objective systemic lupus erythematosus sle is a chronic autoimmune disease. The performances of the acr 1997, slicc 2012, and eular. Application of the 2012 systemic lupus international. Slicc classification criteria for sle current medical. Individually, the positive ana criterion had 100% sensitivity but only 58. Evaluation of the slicc classification criteria in. In 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc 12 to classify systemic. In 2012, the systemic lupus international collaborating clinics slicc validated new sle. In 2012, the systemic lupus international collaborating clinics slicc proposed revised classification criteria were released in an effort to improve upon the 1997 american college of rheumatology acr classification criteria. The most widely used and accepted criteria have been the 1997 acr criteria. Derivation and validation of systemic lupus international.
The 2012 revised slicc criteria for classification of. Slicc criteria for systemic lupus erythematosus sle diagnosis. In light of the increased weight of renal lupus in the slicc classification and the. Conclusions the slicc criteria classify more subjects with sle than acr criteria. The most widely used and accepted criteria has been the 1997 acr criteria. Navarra sv, guzman rm, gallacher ae, hall s, levy ra, jimenez re, li ekm, thomas m, kim hy, leon mg, tanasescu c, nasonov e, lan jl, pinela l, zhong zj, freimuth w, petri ma.
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